Drug interactions
Glibenclamide + Safinamide
Severity: Moderate
Glibenclamide and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide is a BCRP substrate, and safinamide can inhibit intestinal BCRP, which may raise glyburide absorption. This could increase the glucose-lowering effect and the risk of hypoglycemia.
What this interaction means in plain words
Glibenclamide and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Safinamide belongs to Central Nervous System.
Why it happens
Safinamide inhibits intestinal BCRP, increasing the oral absorption of glyburide.
What to do
Monitor blood glucose when safinamide is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Safinamide?
MediHelp rates the interaction as moderate. Glibenclamide and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide is a BCRP substrate, and safinamide can inhibit intestinal BCRP, which may raise glyburide absorption. This could increase the glucose-lowering effect and the risk of hypoglycemia.
How serious is the interaction between Glibenclamide and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when safinamide is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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