Drug interactions
Glibenclamide + Somatrogon
Severity: Moderate
Glibenclamide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon is a growth hormone analogue that reduces insulin sensitivity and can raise blood glucose. In patients taking glyburide, glycemic control may deteriorate. Patients with diabetes or impaired glucose tolerance are at greater risk.
What this interaction means in plain words
Glibenclamide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance opposes the glucose-lowering action of glyburide.
What to do
Monitor blood glucose after starting somatrogon or changing its dose. Adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Glibenclamide with Somatrogon?
MediHelp rates the interaction as moderate. Glibenclamide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon is a growth hormone analogue that reduces insulin sensitivity and can raise blood glucose. In patients taking glyburide, glycemic control may deteriorate. Patients with diabetes or impaired glucose tolerance are at greater risk.
How serious is the interaction between Glibenclamide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting somatrogon or changing its dose. Adjust the glyburide dose as needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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