Drug interactions
Glibenclamide + Valsartan
Severity: Minor
Glibenclamide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit OATP1B1 and could slightly raise valsartan levels, though this is mostly theoretical. Valsartan may also modestly improve insulin sensitivity, so glucose control can shift.
What this interaction means in plain words
Glibenclamide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition by glyburide reducing hepatic uptake of valsartan; based on in vitro data.
What to do
No dose change is routinely required; monitor blood pressure and blood glucose when starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Valsartan?
MediHelp rates the interaction as minor. Glibenclamide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit OATP1B1 and could slightly raise valsartan levels, though this is mostly theoretical. Valsartan may also modestly improve insulin sensitivity, so glucose control can shift.
How serious is the interaction between Glibenclamide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor blood pressure and blood glucose when starting either drug.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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