Drug interactions
Gliclazide + Gymnema
Severity: Moderate
Gliclazide and Gymnema: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has glucose-lowering activity and may add to the effect of gliclazide, raising the risk of hypoglycaemia. Data are limited but the effect is plausible.
What this interaction means in plain words
Gliclazide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypoglycaemic effect, possibly through enhanced insulin secretion and reduced intestinal glucose absorption.
What to do
Monitor blood glucose closely if the herb is used and reduce the gliclazide dose if hypoglycaemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Gymnema?
MediHelp rates the interaction as moderate. Gliclazide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has glucose-lowering activity and may add to the effect of gliclazide, raising the risk of hypoglycaemia. Data are limited but the effect is plausible.
How serious is the interaction between Gliclazide and Gymnema?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if the herb is used and reduce the gliclazide dose if hypoglycaemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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