Drug interactions
Gliclazide + Hydrocortisone
Severity: Moderate
Gliclazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids promote hepatic glucose output and insulin resistance, which can raise blood glucose and blunt the effect of gliclazide. Glycemic control may deteriorate, especially with higher doses or prolonged courses.
What this interaction means in plain words
Gliclazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced gluconeogenesis and peripheral insulin resistance.
What to do
Monitor blood glucose more often during systemic hydrocortisone therapy and increase the gliclazide dose if needed. Reduce the dose again when the corticosteroid is tapered or stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Gliclazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Gliclazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids promote hepatic glucose output and insulin resistance, which can raise blood glucose and blunt the effect of gliclazide. Glycemic control may deteriorate, especially with higher doses or prolonged courses.
How serious is the interaction between Gliclazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during systemic hydrocortisone therapy and increase the gliclazide dose if needed. Reduce the dose again when the corticosteroid is tapered or stopped to avoid hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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