Drug interactions
Gliclazide + Ibuprofen / famotidine
Severity: Minor
Gliclazide and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may modestly enhance the glucose-lowering effect of sulfonylureas, though clinical effects are usually small. The rationale based on gastric pH is not convincing for gliclazide.
What this interaction means in plain words
Gliclazide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAIDs may weakly potentiate sulfonylurea effect through protein binding or CYP2C9 competition; famotidine has little relevant effect.
What to do
Monitor blood glucose if ibuprofen is used regularly and reduce gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Gliclazide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen may modestly enhance the glucose-lowering effect of sulfonylureas, though clinical effects are usually small. The rationale based on gastric pH is not convincing for gliclazide.
How serious is the interaction between Gliclazide and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if ibuprofen is used regularly and reduce gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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