Drug interactions
Gliclazide + Indinavir
Severity: Moderate
Gliclazide and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir has been linked to insulin resistance and hyperglycemia, which can reduce the effectiveness of gliclazide. New or worsening diabetes has been reported with protease inhibitors.
What this interaction means in plain words
Gliclazide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors may inhibit glucose transporter GLUT4 and cause insulin resistance, opposing sulfonylurea action.
What to do
Monitor blood glucose and HbA1c after starting indinavir and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Indinavir?
MediHelp rates the interaction as moderate. Gliclazide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir has been linked to insulin resistance and hyperglycemia, which can reduce the effectiveness of gliclazide. New or worsening diabetes has been reported with protease inhibitors.
How serious is the interaction between Gliclazide and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting indinavir and adjust antidiabetic therapy as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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