Drug interactions
Gliclazide + Insulin lispro protamine / insulin lispro
Severity: Moderate
Gliclazide and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin lispro mixtures with gliclazide produces additive glucose lowering and raises the risk of hypoglycemia. Doses often need adjustment when the combination is begun.
What this interaction means in plain words
Gliclazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Exogenous insulin and sulfonylurea-stimulated endogenous insulin release have additive glucose-lowering effects.
What to do
Monitor blood glucose and reduce gliclazide or insulin dose if hypoglycemia occurs, particularly when starting or intensifying therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Gliclazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin lispro mixtures with gliclazide produces additive glucose lowering and raises the risk of hypoglycemia. Doses often need adjustment when the combination is begun.
How serious is the interaction between Gliclazide and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce gliclazide or insulin dose if hypoglycemia occurs, particularly when starting or intensifying therapy.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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