Drug interactions
Gliclazide + Insulin lispro
Severity: Moderate
Gliclazide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with rapid-acting insulin produces additive glucose lowering and increases the risk of hypoglycemia. The combination is used deliberately but often requires dose reductions.
What this interaction means in plain words
Gliclazide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor blood glucose frequently when starting, adjusting or stopping either drug. Reduce the gliclazide or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Insulin lispro
Frequently asked questions
Can I take Gliclazide with Insulin lispro?
MediHelp rates the interaction as moderate. Gliclazide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with rapid-acting insulin produces additive glucose lowering and increases the risk of hypoglycemia. The combination is used deliberately but often requires dose reductions.
How serious is the interaction between Gliclazide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, adjusting or stopping either drug. Reduce the gliclazide or insulin dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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