Drug interactions
Gliclazide + Insulin nph
Severity: Moderate
Gliclazide and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gliclazide and NPH insulin both lower blood glucose, so using them together can produce additive glucose lowering and a higher risk of hypoglycemia. The combination is common and often intended, but doses may need to change when either agent is started, stopped or adjusted.
What this interaction means in plain words
Gliclazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: sulfonylurea-stimulated insulin secretion plus exogenous insulin.
What to do
Monitor blood glucose closely when starting or changing either drug and reduce the insulin or gliclazide dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Insulin nph?
MediHelp rates the interaction as moderate. Gliclazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gliclazide and NPH insulin both lower blood glucose, so using them together can produce additive glucose lowering and a higher risk of hypoglycemia. The combination is common and often intended, but doses may need to change when either agent is started, stopped or adjusted.
How serious is the interaction between Gliclazide and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or changing either drug and reduce the insulin or gliclazide dose if hypoglycemia occurs. Educate the patient on recognising and treating hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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