Drug interactions
Gliclazide + Isoniazid
Severity: Minor
Gliclazide and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs in some patients. The effect is inconsistent and is generally of limited clinical importance.
What this interaction means in plain words
Gliclazide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Mechanism not firmly established; altered carbohydrate metabolism has been proposed.
What to do
Monitor blood glucose during isoniazid treatment, particularly at initiation. Increase the gliclazide dose if hyperglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Isoniazid
Frequently asked questions
Can I take Gliclazide with Isoniazid?
MediHelp rates the interaction as minor. Gliclazide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs in some patients. The effect is inconsistent and is generally of limited clinical importance.
How serious is the interaction between Gliclazide and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid treatment, particularly at initiation. Increase the gliclazide dose if hyperglycemia develops.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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