Drug interactions
Gliclazide + Ketorolac intranasal
Severity: Minor
Gliclazide and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can occasionally potentiate sulfonylurea hypoglycemia. With intranasal ketorolac, systemic exposure is lower than with oral dosing and short-term use is typical, so the effect on gliclazide is likely small.
What this interaction means in plain words
Gliclazide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not well established; possible displacement from protein binding or effects on prostaglandin-mediated insulin secretion and renal function.
What to do
No routine dose change is needed; advise patients to watch for hypoglycemia symptoms and check glucose if ketorolac is used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Ketorolac intranasal?
MediHelp rates the interaction as minor. Gliclazide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can occasionally potentiate sulfonylurea hypoglycemia. With intranasal ketorolac, systemic exposure is lower than with oral dosing and short-term use is typical, so the effect on gliclazide is likely small.
How serious is the interaction between Gliclazide and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; advise patients to watch for hypoglycemia symptoms and check glucose if ketorolac is used repeatedly.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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