Drug interactions
Gliclazide + Ketorolac
Severity: Moderate
Gliclazide and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac may enhance the hypoglycemic effect of gliclazide. Ketorolac can also reduce renal function, which may prolong sulfonylurea effects.
What this interaction means in plain words
Gliclazide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and NSAID-related renal impairment; not firmly established.
What to do
Monitor blood glucose and renal function during the short ketorolac course. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Gliclazide with Ketorolac?
MediHelp rates the interaction as moderate. Gliclazide and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac may enhance the hypoglycemic effect of gliclazide. Ketorolac can also reduce renal function, which may prolong sulfonylurea effects.
How serious is the interaction between Gliclazide and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during the short ketorolac course. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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