Drug interactions
Gliclazide + Lofepramine
Severity: Minor
Gliclazide and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as lofepramine may alter glycaemic control and occasionally enhance the effect of sulfonylureas. The clinical effect is generally small.
What this interaction means in plain words
Gliclazide and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not well established; tricyclics may influence insulin sensitivity and glucose regulation.
What to do
Monitor blood glucose when lofepramine is started or stopped and adjust gliclazide if hypoglycaemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Lofepramine?
MediHelp rates the interaction as minor. Gliclazide and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as lofepramine may alter glycaemic control and occasionally enhance the effect of sulfonylureas. The clinical effect is generally small.
How serious is the interaction between Gliclazide and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lofepramine is started or stopped and adjust gliclazide if hypoglycaemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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