Drug interactions
Gliclazide + Lonapegsomatropin
Severity: Moderate
Gliclazide and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of gliclazide. Patients with diabetes may need higher doses of antidiabetic drugs.
What this interaction means in plain words
Gliclazide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance.
What to do
Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin and increase antidiabetic therapy as needed. Reassess doses if growth hormone is reduced or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Lonapegsomatropin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Gliclazide with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Gliclazide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone products can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of gliclazide. Patients with diabetes may need higher doses of antidiabetic drugs.
How serious is the interaction between Gliclazide and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin and increase antidiabetic therapy as needed. Reassess doses if growth hormone is reduced or stopped.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
