Drug interactions
Gliclazide + Lumacaftor / ivacaftor
Severity: Moderate
Gliclazide and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer of CYP enzymes, including CYP2C9, which contributes to gliclazide clearance. Gliclazide levels may fall and glucose control may worsen.
What this interaction means in plain words
Gliclazide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9, increasing gliclazide metabolism.
What to do
Monitor blood glucose closely when the combination is started or stopped and titrate the gliclazide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Gliclazide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an inducer of CYP enzymes, including CYP2C9, which contributes to gliclazide clearance. Gliclazide levels may fall and glucose control may worsen.
How serious is the interaction between Gliclazide and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when the combination is started or stopped and titrate the gliclazide dose accordingly.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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