Drug interactions
Gliclazide + Meclofenamate
Severity: Moderate
Gliclazide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate may potentiate the hypoglycemic effect of sulfonylureas, particularly in patients with reduced kidney function. The effect is usually modest but hypoglycemia can occur.
What this interaction means in plain words
Gliclazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possibly CYP2C9 competition or protein-binding displacement plus prostaglandin effects on insulin secretion; not fully established.
What to do
Monitor blood glucose when starting or stopping meclofenamate and reduce the gliclazide dose if hypoglycemia occurs. Check renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Meclofenamate?
MediHelp rates the interaction as moderate. Gliclazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate may potentiate the hypoglycemic effect of sulfonylureas, particularly in patients with reduced kidney function. The effect is usually modest but hypoglycemia can occur.
How serious is the interaction between Gliclazide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping meclofenamate and reduce the gliclazide dose if hypoglycemia occurs. Check renal function in at-risk patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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