Drug interactions
Gliclazide + Methyclothiazide
Severity: Minor
Gliclazide and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide, a thiazide diuretic, may raise blood glucose and reduce the effect of gliclazide. The effect is more evident at higher doses.
What this interaction means in plain words
Gliclazide and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-related hypokalaemia, reduced insulin secretion and decreased insulin sensitivity oppose the sulfonylurea effect.
What to do
Monitor blood glucose after starting or changing the thiazide and adjust the antidiabetic regimen if needed. Monitor potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Methyclothiazide?
MediHelp rates the interaction as minor. Gliclazide and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methyclothiazide, a thiazide diuretic, may raise blood glucose and reduce the effect of gliclazide. The effect is more evident at higher doses.
How serious is the interaction between Gliclazide and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide and adjust the antidiabetic regimen if needed. Monitor potassium.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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