Drug interactions
Gliclazide + Methyltestosterone
Severity: Moderate
Gliclazide and Methyltestosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens such as methyltestosterone can improve insulin sensitivity and lower blood glucose, which may enhance gliclazide and increase hypoglycaemia risk.
What this interaction means in plain words
Gliclazide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgens may increase insulin sensitivity and alter glucose metabolism, adding to the sulfonylurea effect.
What to do
Monitor blood glucose when starting or stopping the androgen and reduce the gliclazide dose if hypoglycaemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Methyltestosterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Methyltestosterone?
MediHelp rates the interaction as moderate. Gliclazide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens such as methyltestosterone can improve insulin sensitivity and lower blood glucose, which may enhance gliclazide and increase hypoglycaemia risk.
How serious is the interaction between Gliclazide and Methyltestosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the androgen and reduce the gliclazide dose if hypoglycaemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
