Drug interactions
Gliclazide + Mipomersen
Severity: Minor
Gliclazide and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can raise liver enzymes and cause hepatic fat accumulation, and sulfonylureas rarely cause liver injury. No meaningful pharmacokinetic or glycemic interaction is established, so the concern is additive hepatic burden.
What this interaction means in plain words
Gliclazide and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes as required for mipomersen therapy and review treatment if significant elevations occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Mipomersen?
MediHelp rates the interaction as minor. Gliclazide and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen can raise liver enzymes and cause hepatic fat accumulation, and sulfonylureas rarely cause liver injury. No meaningful pharmacokinetic or glycemic interaction is established, so the concern is additive hepatic burden.
How serious is the interaction between Gliclazide and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes as required for mipomersen therapy and review treatment if significant elevations occur.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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