Drug interactions
Gliclazide + Oxandrolone
Severity: Moderate
Gliclazide and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic androgenic steroids such as oxandrolone can improve insulin sensitivity and lower blood glucose. When given with gliclazide, the glucose-lowering effect may be enhanced and hypoglycemia can occur, particularly in elderly patients or those with renal impairment.
What this interaction means in plain words
Gliclazide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effect from increased insulin sensitivity combined with sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose more frequently when starting or stopping oxandrolone and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Oxandrolone?
MediHelp rates the interaction as moderate. Gliclazide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic androgenic steroids such as oxandrolone can improve insulin sensitivity and lower blood glucose. When given with gliclazide, the glucose-lowering effect may be enhanced and hypoglycemia can occur, particularly in elderly patients or those with renal impairment.
How serious is the interaction between Gliclazide and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping oxandrolone and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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