Drug interactions
Gliclazide + Oxymetholone
Severity: Moderate
Gliclazide and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone, an anabolic steroid, may lower blood glucose and increase sensitivity to antidiabetic drugs. Combined with gliclazide, this can lead to hypoglycemia, especially in patients with reduced renal or hepatic function.
What this interaction means in plain words
Gliclazide and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effect through improved insulin sensitivity alongside sulfonylurea-stimulated insulin release.
What to do
Monitor blood glucose closely when oxymetholone is started, adjusted or stopped, and lower the gliclazide dose if glucose falls too low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Oxymetholone?
MediHelp rates the interaction as moderate. Gliclazide and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone, an anabolic steroid, may lower blood glucose and increase sensitivity to antidiabetic drugs. Combined with gliclazide, this can lead to hypoglycemia, especially in patients with reduced renal or hepatic function.
How serious is the interaction between Gliclazide and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when oxymetholone is started, adjusted or stopped, and lower the gliclazide dose if glucose falls too low.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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