Drug interactions
Gliclazide + Perindopril
Severity: Minor
Gliclazide and Perindopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity and occasionally cause hypoglycemia in patients taking sulfonylureas. The effect is uncommon and mainly seen early in therapy.
What this interaction means in plain words
Gliclazide and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Improved insulin sensitivity, possibly via bradykinin, adds to the sulfonylurea effect.
What to do
Advise the patient on hypoglycemia symptoms and monitor glucose when perindopril is started. Reduce gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Gliclazide with Perindopril?
MediHelp rates the interaction as minor. Gliclazide and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may improve insulin sensitivity and occasionally cause hypoglycemia in patients taking sulfonylureas. The effect is uncommon and mainly seen early in therapy.
How serious is the interaction between Gliclazide and Perindopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient on hypoglycemia symptoms and monitor glucose when perindopril is started. Reduce gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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