Drug interactions
Gliclazide + Pindolol
Severity: Moderate
Gliclazide and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and may prolong recovery from low glucose. Pindolol has intrinsic sympathomimetic activity, which may lessen this, but the risk remains.
What this interaction means in plain words
Gliclazide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade blunts hypoglycemia symptoms and counter-regulation, and may modestly impair glucose control.
What to do
Monitor blood glucose more often and counsel the patient that sweating may be the main warning sign of hypoglycemia. Consider a cardioselective beta-blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Pindolol?
MediHelp rates the interaction as moderate. Gliclazide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and may prolong recovery from low glucose. Pindolol has intrinsic sympathomimetic activity, which may lessen this, but the risk remains.
How serious is the interaction between Gliclazide and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and counsel the patient that sweating may be the main warning sign of hypoglycemia. Consider a cardioselective beta-blocker if one is needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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