Drug interactions
Gliclazide + Propranolol
Severity: Moderate
Gliclazide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can mask the adrenergic warning signs of hypoglycemia and delay recovery, and may impair glycemic control. This raises the risk of unrecognized or prolonged hypoglycemia with sulfonylureas.
What this interaction means in plain words
Gliclazide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta blockade suppresses counter-regulatory responses, symptom recognition and glycogenolysis.
What to do
Monitor blood glucose more frequently and warn the patient that sweating may be the only symptom. Prefer a cardioselective beta blocker if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Gliclazide with Propranolol?
MediHelp rates the interaction as moderate. Gliclazide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can mask the adrenergic warning signs of hypoglycemia and delay recovery, and may impair glycemic control. This raises the risk of unrecognized or prolonged hypoglycemia with sulfonylureas.
How serious is the interaction between Gliclazide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and warn the patient that sweating may be the only symptom. Prefer a cardioselective beta blocker if appropriate.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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