Drug interactions
Gliclazide + Quinapril
Severity: Minor
Gliclazide and Quinapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. The effect is usually mild.
What this interaction means in plain words
Gliclazide and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic synergy through improved insulin sensitivity, possibly via bradykinin-mediated effects.
What to do
Monitor blood glucose when starting quinapril, especially in the first weeks, and adjust gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Quinapril?
MediHelp rates the interaction as minor. Gliclazide and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. The effect is usually mild.
How serious is the interaction between Gliclazide and Quinapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting quinapril, especially in the first weeks, and adjust gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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