Drug interactions
Gliclazide + Rifampin
Severity: Moderate
Gliclazide and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces enzymes that metabolise gliclazide, lowering its levels and reducing glucose control. Hyperglycemia may develop within days and reverse after rifampin is stopped.
What this interaction means in plain words
Gliclazide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C9 and CYP2C19 increases gliclazide clearance.
What to do
Monitor blood glucose and increase the gliclazide dose or add other therapy as needed. Reduce the dose again, with monitoring, after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Rifampin?
MediHelp rates the interaction as moderate. Gliclazide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces enzymes that metabolise gliclazide, lowering its levels and reducing glucose control. Hyperglycemia may develop within days and reverse after rifampin is stopped.
How serious is the interaction between Gliclazide and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and increase the gliclazide dose or add other therapy as needed. Reduce the dose again, with monitoring, after rifampin is stopped.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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