Drug interactions
Gliclazide + Salsalate
Severity: Moderate
Gliclazide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is metabolised to salicylic acid, which can lower blood glucose and may enhance the effect of sulfonylureas, leading to hypoglycemia. Risk is higher at regular anti-inflammatory doses.
What this interaction means in plain words
Gliclazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering by salicylate with possible protein-binding displacement.
What to do
Monitor blood glucose when salsalate is started, changed or stopped and reduce the gliclazide dose if glucose falls too low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Salsalate?
MediHelp rates the interaction as moderate. Gliclazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is metabolised to salicylic acid, which can lower blood glucose and may enhance the effect of sulfonylureas, leading to hypoglycemia. Risk is higher at regular anti-inflammatory doses.
How serious is the interaction between Gliclazide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when salsalate is started, changed or stopped and reduce the gliclazide dose if glucose falls too low.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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