Drug interactions
Gliclazide + Sulfadiazine
Severity: Moderate
Gliclazide and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can potentiate sulfonylurea hypoglycemia, and severe hypoglycemia has been reported. The risk is greatest in older patients and those with renal impairment.
What this interaction means in plain words
Gliclazide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfadiazine may inhibit CYP2C9 metabolism of the sulfonylurea and displace it from plasma protein, and may itself have an insulin-secretagogue effect.
What to do
Monitor blood glucose closely during co-administration and educate the patient about hypoglycemia symptoms; reduce the gliclazide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Sulfadiazine?
MediHelp rates the interaction as moderate. Gliclazide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibacterials can potentiate sulfonylurea hypoglycemia, and severe hypoglycemia has been reported. The risk is greatest in older patients and those with renal impairment.
How serious is the interaction between Gliclazide and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-administration and educate the patient about hypoglycemia symptoms; reduce the gliclazide dose if glucose falls.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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