Drug interactions
Gliclazide + Sulfamethoxypyridazine
Severity: Moderate
Gliclazide and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting sulfonamides can increase the hypoglycemic effect of sulfonylureas. This may lead to unexpectedly low blood glucose.
What this interaction means in plain words
Gliclazide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely CYP2C9 inhibition and protein-binding displacement of the sulfonylurea, plus possible intrinsic hypoglycemic effect.
What to do
Monitor blood glucose during co-administration and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Gliclazide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting sulfonamides can increase the hypoglycemic effect of sulfonylureas. This may lead to unexpectedly low blood glucose.
How serious is the interaction between Gliclazide and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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