Drug interactions
Gliclazide + Sulfisoxazole
Severity: Moderate
Gliclazide and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole may potentiate the effect of sulfonylureas and has been associated with hypoglycemia. The risk is higher in older or renally impaired patients.
What this interaction means in plain words
Gliclazide and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9-mediated sulfonylurea metabolism and displacement from plasma proteins.
What to do
Monitor blood glucose closely and reduce the gliclazide dose if glucose falls; consider a non-sulfonamide antibiotic if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Sulfisoxazole?
MediHelp rates the interaction as moderate. Gliclazide and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole may potentiate the effect of sulfonylureas and has been associated with hypoglycemia. The risk is higher in older or renally impaired patients.
How serious is the interaction between Gliclazide and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose if glucose falls; consider a non-sulfonamide antibiotic if appropriate.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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