Drug interactions
Gliclazide + Willow bark
Severity: Minor
Gliclazide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylates. High salicylate doses can lower blood glucose and may enhance sulfonylurea effects, but the amounts in typical willow bark products are low.
What this interaction means in plain words
Gliclazide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylates have intrinsic glucose-lowering effects and can displace sulfonylureas from plasma proteins, mainly at high doses.
What to do
Monitor blood glucose if willow bark is taken regularly or in large amounts and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Willow bark?
MediHelp rates the interaction as minor. Gliclazide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylates. High salicylate doses can lower blood glucose and may enhance sulfonylurea effects, but the amounts in typical willow bark products are low.
How serious is the interaction between Gliclazide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if willow bark is taken regularly or in large amounts and counsel on hypoglycemia symptoms.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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