Drug interactions
Glimepiride-pioglitazone + Ibuprofen
Severity: Moderate
Glimepiride-pioglitazone and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may modestly enhance the hypoglycemic effect of glimepiride. The interaction is usually mild but relevant in older or renally impaired patients.
What this interaction means in plain words
Glimepiride-pioglitazone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and CYP2C9 competition; mechanism not firmly established.
What to do
Monitor blood glucose when the NSAID is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ibuprofen?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may modestly enhance the hypoglycemic effect of glimepiride. The interaction is usually mild but relevant in older or renally impaired patients.
How serious is the interaction between Glimepiride-pioglitazone and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the NSAID is started or stopped and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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