Drug interactions
Glimepiride-pioglitazone + Imipramine
Severity: Minor
Glimepiride-pioglitazone and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance glucose lowering and have been linked to hypoglycemia in patients on antidiabetic drugs. They can also mask adrenergic warning symptoms of hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Probable pharmacodynamic additive effect on glucose lowering; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping imipramine and counsel patients about hypoglycemia, particularly with glimepiride.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride-pioglitazone and Imipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Imipramine?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may enhance glucose lowering and have been linked to hypoglycemia in patients on antidiabetic drugs. They can also mask adrenergic warning symptoms of hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping imipramine and counsel patients about hypoglycemia, particularly with glimepiride.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
