Drug interactions
Glimepiride-pioglitazone + Isocarboxazid
Severity: Moderate
Glimepiride-pioglitazone and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can enhance the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The effect may be unpredictable and can be pronounced in some patients.
What this interaction means in plain words
Glimepiride-pioglitazone and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion or sensitivity and impair counter-regulation; the exact mechanism is not well established.
What to do
Monitor blood glucose frequently when starting or stopping the MAO inhibitor and lower the glimepiride dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Isocarboxazid?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can enhance the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The effect may be unpredictable and can be pronounced in some patients.
How serious is the interaction between Glimepiride-pioglitazone and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or stopping the MAO inhibitor and lower the glimepiride dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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