Drug interactions
Glimepiride-pioglitazone + Ivosidenib
Severity: Moderate
Glimepiride-pioglitazone and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9 and CYP3A4, which may lower glimepiride concentrations and weaken glycemic control. Pioglitazone, metabolized by CYP2C8 and CYP3A4, may also be reduced.
What this interaction means in plain words
Glimepiride-pioglitazone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9 and CYP3A4, increasing clearance of glimepiride and pioglitazone.
What to do
Monitor blood glucose and HbA1c after starting ivosidenib. Adjust antidiabetic doses or change therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ivosidenib?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9 and CYP3A4, which may lower glimepiride concentrations and weaken glycemic control. Pioglitazone, metabolized by CYP2C8 and CYP3A4, may also be reduced.
How serious is the interaction between Glimepiride-pioglitazone and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting ivosidenib. Adjust antidiabetic doses or change therapy if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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