Drug interactions
Glimepiride-pioglitazone + Lisinopril
Severity: Minor
Glimepiride-pioglitazone and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Glimepiride-pioglitazone and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may increase insulin sensitivity through bradykinin-related effects and improved peripheral glucose uptake.
What to do
Monitor blood glucose when starting the ACE inhibitor, especially in the first weeks. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Lisinopril?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually modest.
How serious is the interaction between Glimepiride-pioglitazone and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting the ACE inhibitor, especially in the first weeks. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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