Drug interactions
Glimepiride-pioglitazone + Moexipril
Severity: Minor
Glimepiride-pioglitazone and Moexipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Glimepiride-pioglitazone and Moexipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
ACE inhibition may increase insulin sensitivity and glucose uptake through bradykinin-related mechanisms.
What to do
Monitor blood glucose when starting the ACE inhibitor and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride-pioglitazone and Moexipril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Moexipril?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Moexipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually modest.
How serious is the interaction between Glimepiride-pioglitazone and Moexipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting the ACE inhibitor and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
