Drug interactions
Glimepiride-pioglitazone + Nilotinib
Severity: Minor
Glimepiride-pioglitazone and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and CYP2C8 in vitro and may raise pioglitazone exposure. Nilotinib itself can alter blood glucose, so glycemic changes may be unpredictable.
What this interaction means in plain words
Glimepiride-pioglitazone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4/CYP2C8-mediated pioglitazone metabolism by nilotinib.
What to do
Monitor blood glucose and signs of fluid retention while on both drugs and reduce pioglitazone if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Nilotinib?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP3A4 and CYP2C8 in vitro and may raise pioglitazone exposure. Nilotinib itself can alter blood glucose, so glycemic changes may be unpredictable.
How serious is the interaction between Glimepiride-pioglitazone and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of fluid retention while on both drugs and reduce pioglitazone if adverse effects emerge.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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