Drug interactions
Glimepiride-pioglitazone + Phenelzine
Severity: Moderate
Glimepiride-pioglitazone and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine can lower blood glucose and potentiate the effect of sulfonylureas, leading to hypoglycemia. The effect may be prolonged and unexpected.
What this interaction means in plain words
Glimepiride-pioglitazone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion and sensitivity; the mechanism is not fully established.
What to do
Monitor blood glucose closely when starting phenelzine and reduce the glimepiride dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Phenelzine?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as phenelzine can lower blood glucose and potentiate the effect of sulfonylureas, leading to hypoglycemia. The effect may be prolonged and unexpected.
How serious is the interaction between Glimepiride-pioglitazone and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting phenelzine and reduce the glimepiride dose if needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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