Drug interactions
Glimepiride-pioglitazone + Rifabutin
Severity: Moderate
Glimepiride-pioglitazone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an inducer of CYP enzymes and may lower pioglitazone and glimepiride exposure, reducing glycemic control. The induction is weaker than with rifampin.
What this interaction means in plain words
Glimepiride-pioglitazone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP2C8, CYP3A4 and CYP2C9 increases metabolism of pioglitazone and glimepiride.
What to do
Monitor blood glucose after starting or stopping rifabutin and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Rifabutin?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is an inducer of CYP enzymes and may lower pioglitazone and glimepiride exposure, reducing glycemic control. The induction is weaker than with rifampin.
How serious is the interaction between Glimepiride-pioglitazone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping rifabutin and adjust antidiabetic doses accordingly.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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