Drug interactions
Glimepiride-pioglitazone + Selegiline
Severity: Moderate
Glimepiride-pioglitazone and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance the glucose-lowering effects of antidiabetic drugs, increasing hypoglycemia risk. Selegiline is a selective MAO-B inhibitor, so the effect is likely smaller.
What this interaction means in plain words
Glimepiride-pioglitazone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition may augment insulin secretion and sensitivity; mechanism not firmly established.
What to do
Monitor blood glucose when selegiline is started and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Selegiline?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may enhance the glucose-lowering effects of antidiabetic drugs, increasing hypoglycemia risk. Selegiline is a selective MAO-B inhibitor, so the effect is likely smaller.
How serious is the interaction between Glimepiride-pioglitazone and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when selegiline is started and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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