Drug interactions
Glimepiride-pioglitazone + Trandolapril
Severity: Moderate
Glimepiride-pioglitazone and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and potentiate the effect of sulfonylureas, occasionally causing hypoglycemia, particularly after initiation.
What this interaction means in plain words
Glimepiride-pioglitazone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect through improved insulin sensitivity, possibly via increased bradykinin.
What to do
Monitor blood glucose when starting trandolapril and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Trandolapril?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and potentiate the effect of sulfonylureas, occasionally causing hypoglycemia, particularly after initiation.
How serious is the interaction between Glimepiride-pioglitazone and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting trandolapril and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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