Drug interactions
Glipizide-metformin + Hydrocortisone
Severity: Moderate
Glipizide-metformin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone raises blood glucose and can reduce the effectiveness of glipizide and metformin. The effect depends on dose and duration.
What this interaction means in plain words
Glipizide-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic glucose production and peripheral insulin resistance.
What to do
Monitor blood glucose more often during corticosteroid therapy and adjust antidiabetic doses, reducing them again when steroids are tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Glipizide-metformin with Hydrocortisone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone raises blood glucose and can reduce the effectiveness of glipizide and metformin. The effect depends on dose and duration.
How serious is the interaction between Glipizide-metformin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during corticosteroid therapy and adjust antidiabetic doses, reducing them again when steroids are tapered.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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