Drug interactions
Glipizide-metformin + Hydroxyprogesterone caproate
Severity: Minor
Glipizide-metformin and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly raise blood glucose and reduce glucose tolerance, which may blunt the effect of glipizide and metformin. The clinical impact is generally small but may matter in patients with poor baseline control.
What this interaction means in plain words
Glipizide-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogenic activity can increase insulin resistance, opposing the effects of antidiabetic drugs.
What to do
Monitor blood glucose when hydroxyprogesterone caproate is started or stopped, and adjust the antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Glipizide-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly raise blood glucose and reduce glucose tolerance, which may blunt the effect of glipizide and metformin. The clinical impact is generally small but may matter in patients with poor baseline control.
How serious is the interaction between Glipizide-metformin and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when hydroxyprogesterone caproate is started or stopped, and adjust the antidiabetic doses if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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