Drug interactions
Glipizide-metformin + Indapamide
Severity: Minor
Glipizide-metformin and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, can modestly raise blood glucose and weaken the effect of glipizide and metformin. The effect is generally small at usual doses.
What this interaction means in plain words
Glipizide-metformin and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia may impair insulin secretion and promote insulin resistance.
What to do
Monitor blood glucose and potassium after starting indapamide and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Indapamide
Frequently asked questions
Can I take Glipizide-metformin with Indapamide?
MediHelp rates the interaction as minor. Glipizide-metformin and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide, a thiazide-like diuretic, can modestly raise blood glucose and weaken the effect of glipizide and metformin. The effect is generally small at usual doses.
How serious is the interaction between Glipizide-metformin and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting indapamide and adjust antidiabetic therapy if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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