Drug interactions
Glipizide-metformin + Ioversol
Severity: Major
Glipizide-metformin and Ioversol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent that can cause acute kidney injury, and metformin depends on renal elimination. Reduced clearance leads to metformin accumulation and raises the risk of lactic acidosis.
What this interaction means in plain words
Glipizide-metformin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-induced reduction in renal function decreases renal elimination of metformin, causing accumulation.
What to do
Hold metformin at the time of or before the procedure in patients with reduced eGFR, liver disease, alcoholism, heart failure or intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Ioversol?
MediHelp rates the interaction as major. Glipizide-metformin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ioversol is an iodinated contrast agent that can cause acute kidney injury, and metformin depends on renal elimination. Reduced clearance leads to metformin accumulation and raises the risk of lactic acidosis.
How serious is the interaction between Glipizide-metformin and Ioversol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with reduced eGFR, liver disease, alcoholism, heart failure or intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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