Drug interactions
Glipizide-metformin + Ketorolac intranasal
Severity: Moderate
Glipizide-metformin and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can occasionally potentiate sulfonylurea hypoglycemia, and ketorolac may impair renal function, which can increase metformin accumulation. Short-term intranasal use carries a modest risk, but caution is relevant in patients with renal impairment.
What this interaction means in plain words
Glipizide-metformin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible displacement of glipizide from protein binding and NSAID-related reduction in renal prostaglandin-dependent perfusion affecting metformin clearance.
What to do
Monitor blood glucose and renal function, and avoid the combination in patients with reduced kidney function or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can occasionally potentiate sulfonylurea hypoglycemia, and ketorolac may impair renal function, which can increase metformin accumulation. Short-term intranasal use carries a modest risk, but caution is relevant in patients with renal impairment.
How serious is the interaction between Glipizide-metformin and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and avoid the combination in patients with reduced kidney function or dehydration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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