Drug interactions
Glipizide-metformin + Ketorolac
Severity: Moderate
Glipizide-metformin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac may enhance glipizide's glucose-lowering effect, and its potent effect on renal prostaglandins can reduce kidney function, which raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Glipizide-metformin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement; NSAID inhibition of renal prostaglandins can reduce renal perfusion and metformin clearance.
What to do
Keep ketorolac courses short and monitor blood glucose and renal function. Avoid in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Ketorolac?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac may enhance glipizide's glucose-lowering effect, and its potent effect on renal prostaglandins can reduce kidney function, which raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Glipizide-metformin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac courses short and monitor blood glucose and renal function. Avoid in patients with renal impairment or dehydration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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