Drug interactions
Glipizide-metformin + Liotrix
Severity: Moderate
Glipizide-metformin and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains thyroid hormones that raise hepatic glucose output and metabolic rate, which can lessen the effect of glipizide and metformin. Reducing or stopping liotrix may lead to hypoglycemia.
What this interaction means in plain words
Glipizide-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase gluconeogenesis, glycogenolysis and glucose absorption, opposing antidiabetic action.
What to do
Monitor blood glucose when liotrix is started, adjusted or stopped, and change the antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Glipizide-metformin with Liotrix?
MediHelp rates the interaction as moderate. Glipizide-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains thyroid hormones that raise hepatic glucose output and metabolic rate, which can lessen the effect of glipizide and metformin. Reducing or stopping liotrix may lead to hypoglycemia.
How serious is the interaction between Glipizide-metformin and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when liotrix is started, adjusted or stopped, and change the antidiabetic doses accordingly.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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